1.

Jemth, P., Stenberg, G., Chaga, G., and Mannervik, B. (1996) Heterologous expression, purification and characterization of rat class theta glutathione transferase T2-2. Biochem. J. 316, 131-136 [abstract]

2.

Bao, Y., Jemth, P., Mannervik, B., and Williamson, G. (1997) Reduction of thymine hydroperoxide by phospholipid hydroperoxide glutathione peroxidase and glutathione transferases. FEBS Lett. 410, 210-212 [abstract]

3.

Jemth, P., and Mannervik, B. (1997) Kinetic characterization of recombinant human glutathione transferase T1-1, a polymorphic detoxication enzyme. Arch. Biochem. Biophys. 348, 247-254 [abstract]

4.

Hurst, R., Bao, Y., Jemth, P., Mannervik, B., and Williamson, G. (1998) Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases. Biochem. J. 332, 97-100 [abstract]

5.

Jemth, P., and Mannervik, B. (1999) Fast product formation and slow product release are important features in a hysteretic reaction mechanism of GST T2-2. Biochemistry 38, 9982-9991 [abstract]

6.

Gustafsson, A., Etahadieh, M., Jemth, P., and Mannervik, B. (1999) The C-terminal region of human glutathione transferase A1-1 affects the rate of glutathione binding and the ionization of the active-site Tyr9. Biochemistry 38, 16268-16275 [abstract]

7.

Jemth, P., and Mannervik, B. (2000) Active-site serine promotes stabilization of the reactive glutathione thiolate in rat glutathione transferase T2-2. Evidence against proposed sulfatase activity of the corresponding human enzyme. J. Biol. Chem. 275, 8618-8624 [abstract]

8.

Ridderström, M., Jemth, P., Cameron, A. D., Jones, T. A., and Mannervik, B. (2000) The active-site residue Tyr-175 in human glyoxalase II contributes to binding of glutathione derivatives. Biochim. Biophys. Acta 1481, 344-348 [abstract]

9.

Frickel, E.-M., Jemth, P., Widersten, M., and Mannervik, B. (2001) Yeast glyoxalase I is a monomeric enzyme with two active sites. J. Biol. Chem. 276, 1845-1849 [abstract]

10.

Gustafsson, A., Pettersson, P. L., Grehn, L., Jemth, P., and Mannervik, B. (2001) The functional role of the glutamyl-α-carboxylate of glutathione in the catalytic mechansim of human glutathione transferase A1-1. Biochemistry 40, 15835-15845 [abstract]

11.

Broo, K., Larsson, A.-K., Jemth, P., and Mannervik, B. (2002) An ensemble of theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes. J. Mol. Biol. 318, 59-70 [abstract]

12.

Ren, X., Jemth, P., Board, P. G., Luo, G., Mannervik, B., Liu, J., Zhang, K., and Shen, J. (2002) A semisynthetic glutathione peroxidase with high catalytic efficiency: selenoglutathione transferase. Chem. Biol. 9, 789-794 [abstract]

13.

Jemth, P., Kreuger, J., Kusche-Gullberg, M., Sturiale, L., GimÈnez-Gallego, G., and Lindahl, U. (2002) Biosynthetic oligosaccharide libraries for identification of protein-binding heparan sulfate motifs. Exploring the structural diversity by screening for fibroblast growth factor (FGF) 1 and FGF2 binding. J. Biol. Chem. 277, 30567-30573 [abstract]

14.

Jemth, P.*, Smeds, E., Do A. T., Hjertson, E., Kimata, E., Lindahl, U., and Kusche-Gullberg, M.* (2003) Oligosaccharide library-based assessment of heparan sulfate 6-O-sulfotransferase substrate specificity. J. Biol. Chem. 278, 24371-24376 [abstract]

15.

Gong, F., Jemth, P., Escobar Galvis, M. L., Vlodavsky, I., Horner, A., Lindahl, U., and Li, J.-P. (2003) Processing of macromolecular heparin by heparanase. J. Biol. Chem. 278, 35152-35158 [abstract]

16.

Jemth, P., Gianni, S., Day, R., Li, B., Johnson, C. M., Daggett, V., and Fersht, A. R. (2004) Demonstration of a low energy on-pathway intermediate in a fast folding protein by kinetics, protein engineering and simulation. Proc. Natl. Acad. Sci. USA 101, 6450-6455 [abstract]

17.

Kreuger, J., Jemth, P., Sander-Lindberg, E., Eliahu, L., Ron, D., Basilico, C., Salmivirta, M., and Lindahl, U. (2005) Fibroblast growth factors share binding sites in heparan sulfate. Biochem. J. 389, 145-150 [abstract]

18.

Jemth, P., Day, R., Gianni, S., Khan, F., Allen, M. D., Daggett, V., and Fersht, A. R. (2005) The structure of the major transition state for folding of an FF domain from experiment and simulation. J. Mol. Biol. 350, 363-378 [abstract]

19.

White, G., Gianni, S., Grossman, G., Jemth, P., Fersht, A. R., and Daggett, V. (2005) Simulation and experiment conspire to reveal cryptic intermediates and the slide from the nucleation-condensation to framework mechanism of folding. J. Mol. Biol. 350, 757-775 [abstract]

20.

Knauth, K., Bex, C., Jemth, P., and Buchberger, A. (2006) Renal cell carcinoma risk in type 2 von Hippel-Lindau disease correlates with defects in pVHL stability and HIF-1 alpha interactions. Oncogene 25, 370-377 [abstract]

21.

Gianni, S., Engström, Å., Larsson, M., Calosci, N., Malatesta, F., Eklund, L., Ngang, C. C., Travaglini-Allocatelli, C., and Jemth, P.* (2005) The kinetics of PDZ domain-ligand interactions and implications for the binding mechanism. J. Biol. Chem. 280, 34805-34812 [abstract]

22.

Chi, C. N., Engström, Å., Gianni, S., Larsson, M., and Jemth, P.* (2006) Two conserved residues govern the salt and pH dependences of the binding reaction of a PDZ domain. J. Biol. Chem. 281, 36811-36818 [abstract]

23.

Gianni, S., Walma, T., Arcovito, A., Calosci, N., Bellelli, A., Engström, Å., Travaglini-Allocatelli, C., Brunori, M., Jemth, P.*, and Vuister, G. W.* (2006) Demonstration of long-range interactions in a PDZ domain by NMR, kinetics and protein engineering. Structure 14, 1801-1809 [abstract]

24.

Gianni, S., Geierhaas, C. D., Calosci, Jemth, P., Vuister, G. W., Travaglini-Allocatelli, C., Vendruscolo, M., and Brunori, M. (2007) A PDZ domain recapitulates the unifying mechanism for protein folding. Proc. Natl. Acad. Sci. USA 104, 128-133 [abstract]

25.

Ivarsson, Y., Travaglini-Allocatelli, C., Jemth, P., Malatesta, F., Brunori, M., and Gianni, S. (2007) An on-pathway intermediate in the folding of a PDZ domain. J. Biol. Chem. 282, 8568-8572 [abstract]

26.

Chi, C. N., Gianni, S., Calosci, N., Travaglini-Allocatelli, C., Engström, Å., and Jemth, P.* (2007) A conserved folding mechanism for PDZ domains. FEBS Lett. 581, 1109-1113 [abstract]

27.

Jemth, P., Johnson, C. M., Gianni, S., and Fersht, A. R (2008) Demonstration by burst phase analysis of a robust folding intermediate in the FF domain. Prot. Eng. Des. Sel. 21, 207-214 [abstract]

28.

Chi, C. N., Elfström, L., Shi, Y., Engström, Å, Snäll, T., and Jemth, P.* (2008) Reassessing a sparse energetic network within a single protein domain. Proc. Natl. Acad. Sci. USA. 105, 4679-4684 [abstract]

29.

Bach, A., Chi, C. N., Olsen, T. B., Pedersen, S. W., Clausen, R. P., Jemth, P., and Strømgaard, K. (2008) Peptidomimetic inhibitors of the PSD-95/NMDA receptor interaction. J. Med. Chem. 51, 6450-6459 [abstract]

30.

Calosci, N., Chi, C. N., Richter, B., Camilloni, C. Engström, Å, Eklund, L., Travaglini-Allocatelli, C., Gianni, S.*, Vendruscolo, M.* and Jemth, P.* (2008) A comparison of the successive transition states for folding reveals alternative early folding pathways. Proc. Natl. Acad. Sci. USA. 105, 19240-19245 [abstract]

31.

Chi, C. N., Bach, A., Engström, Å, Wang, H., Strømgaard, K., Gianni, S.*, and Jemth, P* (2009) A sequential binding mechanism in a PDZ domain. Biochemistry 48, 7089-7097 [abstract]

32.

Savino, C., Montemiglio, L.C., Sciara, G., Miele, A.E., Kendrew, S.G., Jemth, P., Gianni, S., and Vallone, B. (2009) Investigating the structural plasticity of a cytochrome P450: Three dimensional structures of P450 EryK and binding to its physiological substrate. J. Biol. Chem. 284, 29170-29179 [abstract]

33.

Gianni, S., Brunori, M., Jemth, P., Oliveberg, M., and Zhang, M. (2009) Distinguishing between narrow and broad free energy barriers in protein folding. Biochemistry 48, 11825-11830 [abstract]

34.

Bach, A., Chi, C. N., Pang, G. F., Olsen, L., Kristensen, A. S., Jemth, P., and Strømgaard, K. (2009) Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95/NMDA receptor interaction. Angew. Chem. Int. Ed. 48, 9685 - 9689 [abstract]

35.

Di Matteo, A., Calosci, N., Gianni, S., Jemth, P., Brunori, M., Travaglini-Allocatelli, C. (2010) Structural and functional characterization of CcmG from Pseudomonas aeruginosa, a key component of the bacterial cytochrome c maturation apparatus. Proteins 78, 2213-2221 [abstract]

36.

Haq, S. R., Jürgens, M. C., Chi, C. N., Elfström, L., Koh, C. S., Selmer, M.*, Gianni, S.*, and Jemth, P.* (2010) The plastic energy landscape of protein folding: A triangular folding mechanism with an equilibrium intermediate for a small protein domain. J. Biol. Chem. 285, 18051-18059 [abstract]

37.

Chi, C. N., Bach, A., Gottschalk, M., Kristensen, A. S., Strømgaard, K., and Jemth, P.* (2010) Deciphering the kinetic binding mechanism of dimeric ligands, using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example. J. Biol. Chem. 285, 28252-28260 [abstract]

38.

Chi, C. N., Bach, A., Engstöm, Å., Strømgaard, K., Lundström, P., Ferguson, N., and Jemth, P.* (2011) Biophysical characterization of the complex between human papillomavirus E6 protein and synapse associated protein 97. J. Biol. Chem. 286, 3597-3606 [abstract]. Paper of the week press release. First author profile on Celestine Chi.

39.

Freedman, K., Jürgens, M., Prabhu, A., Jemth, P., Edel, J. B., and Kim, M-J. (2011) Chemical, thermal and electric-induced unfolding of single protein molecules studied using nanopores. Anal. Chem. 83, 5137-5144 [abstract]

40.

Gianni, S., Haq, S. R., Montemiglio, L. C., Jürgens, M. C., Engström, Å., Chi, C. N., Brunori, M., and Jemth, P.* (2011) Sequence specific long-range networks in PDZ domains tune their binding selectivity. J. Biol. Chem. 286, 27167-27175 [abstract]

41.

Haq, S. R., Chi, C. N., Bach, A., Dogan, J., Engström, Å., Hultqvist, G., Karlsson, A., Lundström, P., Montemiglio, L. C., Strømgaard, K., Gianni, S., and Jemth, P.* (2012) Side chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains. J. Am. Chem. Soc. 134, 599-605 [abstract]

42.

Bach, A., Clausen, B. H., Møller, M. M.,Vestergaard, B., Chi, C. N., Round, A., Sørensen, P. L., Nissen, K. B., Sandholm Kastrup, J., Gajhede, M., Jemth, P., Kristensen, A. S., Lundström, P., Lambertsen, K. L., and Strømgaard, K. (2012) Efficient inhibition of PSD-95 with dimeric ligands in vitro and in vivo. Proc. Natl Acad. Sci. USA. 109, 3317-3322. [abstract]

43.

Karlsson, A., Chi, C. N., Engström, Å., and Jemth, P. (2012) The transition state for coupled folding and binding for a flexible beta finger. J. Mol. Biol. In press [abstract]

44.

Hultqvist, G., Pedersen, S. W., Chi, C. N., Strømgaard, K., Gianni, S., and Jemth, P. (2012) An expanded view of the protein folding landscape of PDZ domains. Biochem. Biophys. Res. Commun. In press [abstract]

45.

Giri, R., Morrone, A., Travaglini-Allocatelli, C. Jemth, P., Brunori, M., and Gianni, S. (2012) Nearly identical, yet very different: the folding pathways of proteins with increasing degree of sequence identities but different structure and function. Proc. Natl Acad. Sci. USA. In press.